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Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
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Statin use and all-cause and cancer mortality: BioBank Japan cohort

Hiroshi Yokomichi1, Akiko Nagai2, Makoto Hirata3

  • 1Department of Health Sciences, University of Yamanashi, Yamanashi, Japan.

Journal of Epidemiology
|February 16, 2017
PubMed

Insights

Statins and lifestyle changes show similar survival rates for hyperlipidemia patients. Statin use may offer potential protection against cancer mortality, particularly colorectal cancer.

Area of Science:

  • Cardiovascular Medicine
  • Oncology
  • Pharmacology

Background:

  • Statins are primary treatments for high LDL cholesterol, reducing cardiovascular disease mortality.
  • Limited data exists on non-statin drug effects on mortality and statin's cancer protection.

Purpose of the Study:

  • To compare all-cause and cancer mortality in hyperlipidemia patients with and without statin treatment.

Main Methods:

  • A 12-year follow-up study of 41,930 Japanese hyperlipidemia patients (2003-2007).
  • Kaplan-Meier estimates compared mortality based on statin, non-statin, and lifestyle interventions.
  • Specific analysis of any-organ and colorectal cancer mortality in relation to statin use.

Main Results:

  • Statin monotherapy and lifestyle modification showed comparable survival curves.
  • Statin use indicated a potential, though non-significant, protective effect against colorectal cancer mortality.
  • Resin monotherapy was associated with the lowest overall mortality in the cohort.

Conclusions:

  • Similar mortality rates were observed between statin monotherapy and lifestyle modification.
  • Statin monotherapy may offer potential benefits in reducing any-organ and colorectal cancer-related mortality.
Abstract

Keywords:
Anti-cholesterol agentsColon cancerDyslipidaemiaKaplan–Meier estimateStatins

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