Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Immune Surveillance by NK Cells and Phagocytes

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...

What is Metabolism?

What is Metabolism?

Regulation of Metabolism

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...

Introduction to Metabolism

Introduction to Metabolism

Metabolism encompasses all biochemical reactions in a living organism, facilitating both the breakdown and synthesis of biomolecules. These metabolic processes are categorized into catabolic and anabolic pathways, which operate in a coordinated manner to ensure energy balance and cellular function.Catabolic Pathways and Energy ReleaseCatabolic pathways involve the breakdown of complex macromolecules such as carbohydrates, lipids, and proteins into smaller structures like monosaccharides, fatty...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Macrophage NRF1 promotes mitochondrial protein turnover via the ubiquitin proteasome system to limit mitochondrial stress and inflammation.

Cell reports·2026

Same author

Pharmacologic AMPK Activation Extends Lifespan in <i>C. elegans</i> and Improves Aspects of Healthspan in Mice.

bioRxiv : the preprint server for biology·2026

Same author

Irisin ameliorates obesity and insulin resistance via adipose tissue IL-33 and regulatory T cells.

Nature metabolism·2026

Same author

Author Correction: Piezo1-dependent activation of stromal cells ignites muscle inflammation in exercise and injury and is associated with inflammaging.

Nature immunology·2026

Same author

Piezo1-dependent activation of stromal cells ignites muscle inflammation in exercise and injury and is associated with inflammaging.

Nature immunology·2026

Same author

Regulatory T cells safeguard liver health during metabolic-associated steatohepatitis.

Proceedings of the National Academy of Sciences of the United States of America·2026

Search research articles

Related Experiment Video

Updated: Mar 7, 2026

Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes

Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes

Published on: March 28, 2025

Metabolism Supports Macrophage Activation.

P Kent Langston¹, Munehiko Shibata¹, Tiffany Horng¹

¹Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health , Boston, MA , USA.

Frontiers in Immunology

|February 16, 2017

Summary

Macrophage activation relies on metabolic shifts, which are triggered by polarizing signals. Manipulating macrophage metabolism offers a potential way to regulate their functions in various conditions.

Keywords:

AKT electron transport chain immunometabolism mTOR macrophage macrophage activation macrophage metabolism mitochondria

More Related Videos

Metabolic Characterization of Polarized M1 and M2 Bone Marrow-derived Macrophages Using Real-time Extracellular Flux Analysis

Metabolic Characterization of Polarized M1 and M2 Bone Marrow-derived Macrophages Using Real-time Extracellular Flux Analysis

Published on: November 28, 2015

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Published on: June 23, 2013

Related Experiment Videos

Last Updated: Mar 7, 2026

Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes

Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes

Published on: March 28, 2025

Metabolic Characterization of Polarized M1 and M2 Bone Marrow-derived Macrophages Using Real-time Extracellular Flux Analysis

Metabolic Characterization of Polarized M1 and M2 Bone Marrow-derived Macrophages Using Real-time Extracellular Flux Analysis

Published on: November 28, 2015

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Published on: June 23, 2013

Area of Science:

Immunology
Cell Biology
Metabolism

Background:

Macrophages are crucial immune cells with diverse tissue-specific roles.
Macrophage specialized functions are regulated by polarizing signals that induce transcriptional programs.
Recent research highlights the critical role of metabolic shifts in macrophage activation.

Purpose of the Study:

To review the evolving field of macrophage metabolism.
To discuss how polarizing signals induce metabolic shifts.
To explore the potential of metabolic manipulation for regulating macrophage functions.

Main Methods:

Review of recent scientific literature on macrophage metabolism and activation.
Analysis of signaling pathways that link polarization to metabolic reprogramming.
Discussion of the role of mitochondria in inflammatory macrophage activation.

Main Results:

Metabolic shifts are essential for fueling macrophage activation and effector functions.
Preventing metabolic shifts impairs appropriate macrophage responses.
Mitochondria are identified as central hubs in inflammatory macrophage activation.

Conclusions:

Macrophage activation is intrinsically linked to metabolic reprogramming.
Targeting macrophage metabolism presents a novel therapeutic strategy.
Understanding macrophage metabolic shifts is key to controlling immune responses.