Related Experiment Video
Updated: Mar 7, 2026
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Interesting Correlation Between the Circulating Pentraxin 3 and Cardiac Rehabilitation Program Outcomes in Coronary
Habib Haybar1, Babak Payami1, Isa Khaheshi2
1Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Insights
Pentraxin 3 (PTX3) levels predict cardiac rehabilitation (CR) outcomes in ischemic heart disease (IHD) patients post-coronary artery bypass grafting (CABG). Higher pre-CR PTX3 levels correlate with greater improvements in ejection fraction (EF) and metabolic equivalent (MET).
Area of Science:
- Biomedical research
- Cardiology
- Inflammation markers
Background:
- Pentraxin 3 (PTX3) is an inflammatory mediator elevated in ischemic heart disease (IHD).
- PTX3 may predict outcomes of cardiac rehabilitation (CR) in IHD patients.
- This study investigates PTX3's predictive role in CR outcomes after coronary artery bypass grafting (CABG).
Purpose of the Study:
- To assess the predictive value of circulating Pentraxin 3 (PTX3) levels for cardiac rehabilitation (CR) outcomes.
- To evaluate PTX3's role in patients with ischemic heart disease (IHD) who underwent coronary artery bypass grafting (CABG).
Main Methods:
- One hundred patients undergoing CABG were enrolled.
- PTX3, hs-CRP, ejection fraction (EF), and metabolic equivalent (MET) were measured before and after a 6-week CR program.
- Data were analyzed using SPSS version 22.
Main Results:
- Cardiac rehabilitation significantly improved EF, MET, and PTX3 levels (P < 0.05).
- High-sensitivity C-reactive protein (hs-CRP) showed no significant change (P = 0.546).
- Patients with pre-CR PTX3 levels > 0.40 ng/dL exhibited the most significant improvements in EF and MET.
Conclusions:
- Cardiac rehabilitation programs effectively improve EF and MET in IHD patients post-CABG.
- Pre-treatment PTX3 levels > 0.40 ng/dL identify patients likely to benefit most from CR.
- PTX3 serves as a potential biomarker for predicting CR efficacy in post-CABG patients.
Background:
Pentraxin 3 (PTX3) is an inflammatory mediator, reaches to the high levels after ischemic heart diseases (IHD) and could be a helpful tool to predict cardiac rehabilitation (CR) outcomes. The aim of this study was to investigate the possibility of the circulating levels of PTX3 in prediction of CR outcomes in patients with IHD who had undergone coronary artery bypass grafting (CABG).
Methods:
One hundred patients who had undergone CABG were included in this study. The CR plan was started 6 weeks after CABG and then PTX3 level, high-sensitivity C-reactive protein (hs-CRP), ejection fraction (EF) and metabolic equivalent (MET) were assessed before and after the CR program. Finally, all gathered data were analyzed using SPSS version 22.
Results:
After a 3-month course of CR program, EF, MET, PTX3 and hs-CRP values changed. Statistically significant changes were observed in EF, MET and PTX3 values (P < 0.05) after the CR program and no statistically significant changes were seen in hs-CRP value (P = 0.546) at the end of CR program. Correlations between EF levels and MET with pre-PTX3 levels were also assessed and most changes were observed in the group with pre-PTX3 level more than 0.40 ng/dL.
Conclusion:
Our study showed that a regular sufficient CR program based on exercises in IHD patients after CABG increases EF and MET levels, particularly in those patients with pre-PTX3 levels more than 0.40 ng/dL.
Related Concept Videos
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:27Peripheral Artery Disease III: Interprofessional Care
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:27Coronary Artery Disease V: Interprofessional Care