Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

689
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
689
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

593
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
593
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

564
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
564
Heart Failure Drugs: Inotropic Agents01:26

Heart Failure Drugs: Inotropic Agents

1.7K
Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
1.7K
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

490
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
490
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

694
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
694

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Investigating infective endocarditis: teaching hospitals to choose wisely.

The British journal of cardiology·2024
Same author

Effective orifice diameter: a new sizing parameter of surgical valve prostheses to inform valve selection.

Annals of cardiothoracic surgery·2024
Same author

Drive-by collection and self-fitting of ambulatory electrocardiogram monitoring.

The British journal of cardiology·2022
Same author

Changes and advances in the field of infective endocarditis.

British journal of hospital medicine (London, England : 2005)·2022
Same author

A guide to the management of atrial fibrillation in Santa Claus.

The Medical journal of Australia·2021
Same author

Implications of the 2021 National Institute for Health and Care Excellence atrial fibrillation guidelines.

British journal of hospital medicine (London, England : 2005)·2021

Related Experiment Video

Updated: Mar 7, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

11.1K

Cardiac Resynchronization Therapy Leads to Improvements in Handgrip Strength.

David R Warriner1, Patricia Lawford2, Paul J Sheridan3

  • 1Medical Physics Group, Department of Cardiovascular Science, The Medical School, University of Sheffield, Sheffield, S10 2TN, UK; Department of Cardiology, Northern General Hospital, Sheffield Teaching Hospitals, Sheffield, S5 7AU, UK.

Cardiology Research
|February 16, 2017
PubMed
Summary

Cardiac resynchronization therapy (CRT) significantly improves skeletal muscle function, measured by handgrip strength, in heart failure patients who respond to the treatment. This suggests CRT offers secondary benefits beyond cardiac performance enhancement.

Keywords:
Cardiac resynchronization therapyHandgrip strengthHeart failure

More Related Videos

The Combined Use of Transcranial Direct Current Stimulation and Robotic Therapy for the Upper Limb
14:56

The Combined Use of Transcranial Direct Current Stimulation and Robotic Therapy for the Upper Limb

Published on: September 23, 2018

9.6K
Use of a Foot-Induced Digitally Controlled Resistance Device for Functional Magnetic Resonance Imaging Evaluation in Patients with Foot Paresis
08:55

Use of a Foot-Induced Digitally Controlled Resistance Device for Functional Magnetic Resonance Imaging Evaluation in Patients with Foot Paresis

Published on: July 7, 2023

736

Related Experiment Videos

Last Updated: Mar 7, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

11.1K
The Combined Use of Transcranial Direct Current Stimulation and Robotic Therapy for the Upper Limb
14:56

The Combined Use of Transcranial Direct Current Stimulation and Robotic Therapy for the Upper Limb

Published on: September 23, 2018

9.6K
Use of a Foot-Induced Digitally Controlled Resistance Device for Functional Magnetic Resonance Imaging Evaluation in Patients with Foot Paresis
08:55

Use of a Foot-Induced Digitally Controlled Resistance Device for Functional Magnetic Resonance Imaging Evaluation in Patients with Foot Paresis

Published on: July 7, 2023

736

Area of Science:

  • Cardiology
  • Exercise Physiology
  • Heart Failure Research

Background:

  • Reduced skeletal muscle performance, particularly handgrip strength, is a common issue in heart failure patients.
  • The impact of cardiac resynchronization therapy (CRT) on skeletal muscle function in heart failure has not been previously studied.

Purpose of the Study:

  • To investigate the effect of CRT on skeletal muscle function, specifically handgrip strength, in patients with heart failure.
  • To determine if CRT responders exhibit improvements in skeletal muscle performance.

Main Methods:

  • Nineteen heart failure patients (NYHA class II-IV) underwent CRT.
  • Handgrip strength was measured at baseline and 12 months post-CRT.
  • Treatment response was evaluated using quality of life, 6-minute walk distance, and cardiopulmonary exercise testing.

Main Results:

  • Responders to CRT showed significant increases in both left and right handgrip strength at 12 months (P < 0.001).
  • Non-responders to CRT did not exhibit significant improvements in handgrip strength.
  • Baseline handgrip strength did not differ between responders and non-responders.

Conclusions:

  • Positive response to CRT is linked to substantial improvements in handgrip strength.
  • CRT may indirectly enhance skeletal muscle function in heart failure patients.