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Updated: Mar 7, 2026
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
Novel 18F-Labeled 1-Hydroxyanthraquinone Derivatives for Necrotic Myocardium Imaging
Ai-Yan Ji1, Qiao-Mei Jin2, Dong-Jian Zhang2
1Department of Natural Medicinal Chemistry & Jiangsu Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, Jiangsu, China; Laboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, Jiangsu, China; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, Jiangsu, China.
Insights
A new PET imaging agent, [18F]FA3OP, shows promise for rapidly visualizing necrotic heart tissue after myocardial infarction. This tracer aids in assessing heart viability and guiding treatment decisions for patients.
Area of Science:
- Nuclear Medicine
- Radiochemistry
- Cardiology
Background:
- Accurate assessment of myocardial viability is crucial for revascularization decisions in myocardial infarction (MI) patients.
- Current imaging methods require timely and precise evaluation of necrotic heart tissue.
Purpose of the Study:
- To develop and evaluate novel 18F-labeled 1-hydroxyanthraquinone derivatives as necrosis-avid imaging agents.
- To identify a superior tracer for assessing myocardial viability and visualizing necrotic myocardium.
Main Methods:
- Synthesis and characterization of three novel 18F-labeled compounds.
- Evaluation of tracer stability and targetability in a rat myocardial infarction and reperfusion model.
- Positron Emission Tomography (PET) imaging using the lead compound [18F]FA3OP.
Main Results:
- [18F]FA3OP demonstrated excellent stability and high targetability among the evaluated tracers.
- Clear PET images of necrotic myocardium were obtained in vivo at 1 hour post-injection.
- [18F]FA3OP appears to target necrotic myocardium by intercalating with DNA.
Conclusions:
- [18F]FA3OP is a highly promising "hot spot imaging" tracer for rapid visualization of necrotic myocardium.
- This tracer facilitates precise evaluation of myocardial viability, aiding clinical decision-making for revascularization.
- The DNA intercalation mechanism offers insight into the tracer's targeting specificity.
Abstract:
Rapid detection and precise evaluation of myocardial viability is necessary to aid in clinical decision making whether to recommend revascularization for patients with myocardial infarction (MI). Three novel 18F-labeled 1-hydroxyanthraquinone derivatives were synthesized, characterized, and evaluated as potential necrosis avid imaging agents for assessment of myocardial viability. Among these tracers, [18F]FA3OP emerged as the most promising compound with best stability and highest targetability. Clear PET images of [18F]FA3OP were obtained in rat model of myocardial infarction and reperfusion at 1 h after injection. In addition, the possible mechanisms of [18F]FA3OP for necrotic myocardium were discussed. The results showed [19F]FA3OP may bind DNA to achieve targetability to necrotic myocardium by intercalation. In summary, [18F]FA3OP was a more promising "hot spot imaging" tracer for rapid visualization of necrotic myocardium.
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