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Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish
Published on: May 15, 2021
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Prevention of cisplatin nephrotoxicity
Fatemeh Hayati1, Mehran Hossainzadeh1, Shokouh Shayanpour1
1Chronic Renal Failure Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Journal of Nephropharmacology
|February 16, 2017
Summary
Cisplatin chemotherapy can cause kidney damage (nephrotoxicity), limiting its use. This review explores strategies to prevent cisplatin-induced nephrotoxicity, including hydration and antioxidants.
Area of Science:
- Oncology
- Nephrology
- Pharmacology
Background:
- Cisplatin is a vital chemotherapy drug for various cancers.
- Cisplatin-induced nephrotoxicity (CIN) is a significant dose-limiting side effect, affecting over 50% of patients.
- Risk factors for CIN include high cisplatin doses, prior chemotherapy, kidney issues, and co-administration of nephrotoxic agents.
Purpose of the Study:
- To review current strategies for preventing cisplatin-induced nephrotoxicity.
- To highlight the importance of managing CIN for effective cancer treatment.
Main Methods:
- Literature review of studies on cisplatin nephrotoxicity prevention.
- Analysis of standard prevention protocols and emerging therapeutic approaches.
Main Results:
- Standard CIN prevention involves dose reduction and aggressive intravenous hydration.
- Natural antioxidant compounds show promise in mitigating cisplatin-induced oxidative stress in the kidneys.
- Multiple strategies exist, but careful administration is crucial.
Conclusions:
- Effective prevention and management of CIN are essential for optimizing cisplatin therapy.
- Further research into antioxidant therapies may offer novel approaches to reduce kidney damage.
- A comprehensive approach considering patient factors and treatment protocols is necessary.
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