Related Experiment Video

Updated: Mar 7, 2026

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
07:54

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

7.4K

PIM1 knockdown inhibits cell proliferation and invasion of mesothelioma cells

Amany Sayed Mawas1, Vishwa Jeet Amatya1, Rui Suzuki1

  • 1Department of Pathology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

International Journal of Oncology
|February 16, 2017
PubMed

Insights

Downregulating PIM1 kinase in malignant mesothelioma cells suppressed proliferation and invasion. This suggests targeting PIM1 could be a novel therapeutic strategy for asbestos-related cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Malignant mesothelioma is a serious asbestos-related cancer with poor prognosis.
  • Novel therapeutic strategies are urgently needed for mesothelioma treatment.
  • RNA interference (RNAi) offers a method for gene expression inhibition in cancer therapy.

Purpose of the Study:

  • To investigate the function of PIM1 in mesothelioma.
  • To analyze the effects of PIM1 knockdown on mesothelioma cell behavior.

Main Methods:

  • Utilized small interfering RNA (siRNA) for PIM1 knockdown in mesothelioma cell lines.
  • Assessed the impact of PIM1 downregulation on cell proliferation, cell cycle, invasion, and migration.

Main Results:

  • PIM1 downregulation significantly suppressed mesothelioma cell proliferation.
  • Knockdown of PIM1 induced cell cycle arrest at the G1 phase.
  • Reduced cell invasion and migration was observed following PIM1 suppression.

Conclusions:

  • PIM1 plays a crucial role in mesothelioma cell growth and metastasis.
  • Downregulation of PIM1 demonstrates potential as a therapeutic approach for malignant mesothelioma.
  • Targeting PIM1 may offer a new avenue for managing this aggressive cancer.

More Related Videos

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines08:01

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

2.3K
In vitro Mesothelial Clearance Assay that Models the Early Steps of Ovarian Cancer Metastasis08:54

In vitro Mesothelial Clearance Assay that Models the Early Steps of Ovarian Cancer Metastasis

Published on: February 17, 2012

15.0K

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.3K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.6K