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Related Experiment Video

Updated: Mar 7, 2026

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
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Treated dentin matrix paste as a novel pulp capping agent for dentin regeneration.

Jinlong Chen1,2,3, Caiyun Cui1,2, Xiangchen Qiao1,2

  • 1State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Journal of Tissue Engineering and Regenerative Medicine
|February 16, 2017
PubMed
Summary

Treated dentin matrix paste (TDMP) shows superior biocompatibility and promotes dentin regeneration more effectively than calcium hydroxide (CH). This novel dental pulp capping agent offers a promising alternative for preserving pulp vitality and repairing exposed pulp.

Keywords:
calcium hydroxidedental pulp cappingdentin regenerationtreated dentin matrixvital pulp conservation

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Area of Science:

  • Biomaterials Science
  • Regenerative Dentistry
  • Dental Pulp Biology

Background:

  • Regenerating dentin and preserving pulp vitality are critical for treating dental pulp exposure.
  • Calcium hydroxide (CH), a common pulp capping agent, can cause adverse effects like tunnel defects and pulp inflammation.
  • There is a need for novel pulp capping agents with improved bioactivity and therapeutic outcomes.

Purpose of the Study:

  • To develop and evaluate a novel pulp capping agent, treated dentin matrix paste (TDMP).
  • To assess the chemical, biological, and odontogenic differentiation effects of TDMP.
  • To verify the therapeutic efficacy of TDMP for pulp exposure in vivo.

Main Methods:

  • Fabrication of TDMP from TDM powder and aqueous TDM extract.
  • In vitro assessment of TDMP's biocompatibility, pH, and effects on dental pulp stem cell proliferation.
  • Analysis of gene and protein expression related to odontogenic differentiation (e.g., ALP, BSP, DSP).
  • In vivo study on miniature swine to evaluate pulp capping efficacy and tissue response.

Main Results:

  • TDMP exhibited better biocompatibility and a neutral pH compared to CH.
  • TDMP significantly promoted dental pulp stem cell proliferation and enhanced odontogenic gene/protein expression.
  • In vivo, TDMP resulted in thicker, denser reparative dentin bridges and less pulp inflammation (angiectasis) than CH.

Conclusions:

  • TDMP demonstrates superior performance in promoting dentin regeneration and preserving pulp vitality compared to CH.
  • TDMP possesses enhanced bioactivity and biocompatibility, making it a viable alternative for dental pulp repair.
  • This novel agent holds potential for clinical application in restorative dentistry and endodontics.