Stimuli-responsive liposomes for drug delivery.
1Department of Chemistry, Purdue University, West Lafayette, IN, USA.
Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
|February 16, 2017
Summary
Stimuli-responsive liposomes offer targeted drug delivery by releasing active pharmaceutical ingredients (APIs) at specific sites. This review covers advancements in liposomal systems triggered by pH, enzymes, redox, and light.
Area of Science:
- Nanomedicine
- Biotechnology
- Materials Science
Background:
- Drug delivery aims to enhance bioavailability and reduce toxicity of active pharmaceutical ingredients (APIs).
- Stimuli-responsive systems offer site-selective payload release, minimizing damage to healthy tissues.
- The tumor microenvironment presents unique cues for triggering drug release.
Purpose of the Study:
- To review developments in stimuli-sensitive liposomal drug delivery strategies.
- To focus on literature published between November 2008 and February 2016.
- To explore various activation mechanisms for triggered drug release.
Main Methods:
- Literature review of stimuli-sensitive liposomal drug delivery.
- Analysis of systems triggered by endogenous stimuli (pH, redox, enzymes) and external stimuli (heat, light).
- Focus on liposomal membrane destabilization for drug release.
Main Results:
- Significant progress in stimuli-responsive liposomal formulations.
- Demonstrated efficacy of pH, enzyme, redox, and photochemical triggers for controlled release.
- Enhanced permeation and retention (EPR) effect utilized for improved tumor uptake.
Conclusions:
- Stimuli-sensitive liposomes represent a promising approach for targeted cancer therapy.
- Triggered release mechanisms enhance drug efficacy and reduce systemic toxicity.
- Continued research in this field holds potential for advanced nanomedicine applications.
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