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Published on: May 22, 2017
Cation-Selective Channel Regulated by Anions According to Their Hofmeister Ranking
Philip A Gurnev1, Torri C Roark1,2, Horia I Petrache2
1Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bldg. 9, Rm 1 N-124B, Bethesda, MD, 20892, USA.
Abstract:
Specificity of small ions, the Hofmeister ranking, is long-known and has many applications including medicine. Yet it evades consistent theoretical description. Here we study the effect of Hofmeister anions on gramicidin A channels in lipid membranes. Counterintuitively, we find that conductance of this perfectly cation-selective channel increases about two-fold in the H2 PO4-
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