Characterization of a liquid-filled nodeless anti-resonant fiber for biochemical sensing

We theoretically and experimentally characterize a liquid-filled nodeless anti-resonant fiber (LARF) that could find versatile applications in biochemical sensing. When a hollow-core nodeless anti-resonant fiber (HARF) is filled with a low refractive index liquid such as water or aqueous solutions in the whole hollow area, it preserves its anti-resonant reflection waveguiding mechanism with attributes encompassing the broad transmission bandwidth in UV, visible, and near IR; the neglectable confinement loss; and the acceptable single-mode quality. In comparison with other forms of hollow fiber, the moderate core size of our ARF allows both a large analyte-light overlap integral and a fast liquid flow rate. Such a LARF platform offers a promising route for creating compact, integrable and biocompatible all-fiber multifunctional optofluidic devices for in-situ applications. A proof-of-concept experiment of Raman spectroscopy using ethanol is presented, and applications in fluorescence spectroscopy, resonant Raman spectroscopy, noninvasive biochemical analysis, and interferometric sensing are in prospect.