Increase in the brain regional depolarization-dependent Ca2+ uptake in rats preferring ethanol

The depolarization-dependent Ca2+ uptake system has been suggested to be involved in the release of transmitter and synaptic facilitation. It can be employed as an effective probe to study neurotransmission. Although ethanol has been shown to inhibit or facilitate neurotransmission very little is known about the intrinsic activity of neurotransmission in ethanol-preferring rats. Using the depolarization-dependent Ca2+ uptake system, we demonstrated that synaptic neurotransmission is more active in animals with moderate and high preference for ethanol. Results suggest that there are intrinsic differences in the brain regional neurotransmission among rats showing different degrees of preference for ethanol.