Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Avoidance responding in mice with diabetes mellitus.

L J Leedom, W P Meehan, A Zeidler

    Physiology & Behavior
    |January 1, 1987
    PubMed
    Summary

    Diabetes mellitus in male mice is linked to increased passive avoidance and submissive social behaviors. These behavioral changes suggest neuroendocrine alterations associated with the condition.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Oral Lactobacilli and salivary acidic proline-rich proteins (APRP-1/2) in dental caries.

    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2018
    Same author

    Seasonal changes between one- and two-phasic response of plant leaves to heat stress.

    Oecologia·2017
    Same author

    Metabolic imaging of mild traumatic brain injury.

    Brain imaging and behavior·2012
    Same author

    Cytokine response in patients with chronic infections caused by Staphylococcus aureus strains and diversification of their Agr system classes.

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2012
    Same author

    Protective effect of oral Lactobacilli in pathogenesis of chronic periodontitis.

    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2012
    Same author

    Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis.

    Tissue antigens·2007

    Area of Science:

    • Neuroendocrinology
    • Behavioral Science
    • Diabetes Research

    Background:

    • Diabetes mellitus affects multiple physiological systems.
    • Neuroendocrine dysregulation is a known complication of diabetes.
    • Behavioral changes can be indicators of underlying physiological states.

    Purpose of the Study:

    • To investigate the behavioral effects of diabetes mellitus in a rodent model.
    • To compare the behavior of diabetic and normal male mice.
    • To explore the relationship between specific behaviors and the diabetic state.

    Main Methods:

    • Comparison of diabetic and normal male mice.
    • Assessment of behavior in two distinct paradigms: passive avoidance to shock and social interaction.
    • Statistical analysis to determine significant behavioral differences.

    Main Results:

    • Diabetic mice exhibited significantly higher levels of passive avoidance behavior compared to control mice.
    • Diabetic mice displayed significantly more submissive social behavior than normal mice.
    • A positive correlation was observed between passive avoidance and submissive behavior within the diabetic group.

    Conclusions:

    • Diabetes mellitus is associated with notable alterations in behavioral responses.
    • The neuroendocrine changes in diabetes may manifest as increased passive avoidance and submissiveness.
    • Behavioral paradigms can serve as indicators of the neuroendocrine state in diabetes.

    Related Experiment Videos