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10:19
Screening and Identification of RNA Silencing Suppressors from Secreted Effectors of Plant Pathogens
Published on: February 3, 2020
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Translational control in plant antiviral immunity
João Paulo B Machado1, Iara P Calil1, Anésia A Santos2
1Department of Biochemistry and Molecular Biology, BIOAGRO, National Institute of Science and Technology in Plant-Pest Interactions, Universidade Federal de Viçosa, 36571.000, Viçosa, MG, Brazil.
Genetics and Molecular Biology
|February 16, 2017
Summary
Plants use host protein synthesis machinery for viral replication. To combat this, plants employ translational suppression, including resistance genes and NIK1, to restrict viral infections by hindering protein production.
Area of Science:
- Plant virology
- Molecular biology
- Plant immunity
Background:
- Plant viruses rely on host cell machinery for replication due to limited coding capacity.
- Viruses have evolved strategies to hijack host protein synthesis for efficient viral protein production.
- Plants possess defense mechanisms to restrict viral infections.
Purpose of the Study:
- To review plant strategies for combating viral infections.
- To highlight host-mediated translational suppression as a key antiviral defense.
- To discuss the role of translation initiation factors and NIK1 in plant immunity.
Main Methods:
- Review of existing literature on plant-antiviral interactions.
- Analysis of molecular mechanisms of translational control in plant defense.
- Discussion of genetic and signaling pathways involved in antiviral immunity.
Main Results:
- Plants utilize host-mediated translational suppression to restrict viral infections.
- Resistance genes encoding translation initiation factors (eIF4E, eIF4G) are crucial for antiviral defense.
- Host cells can silence viral RNA by suppressing viral protein translation.
- A novel strategy involves suppression of global host translation mediated by NIK1.
Conclusions:
- Translational suppression is a versatile and effective plant antiviral defense strategy.
- Targeting viral translation initiation and global host translation are key mechanisms.
- Understanding these pathways offers potential for developing novel disease resistance strategies in plants.
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