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Cell-mediated Immune Responses

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Updated: Mar 7, 2026

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Published on: December 22, 2015

Allosensitization Following Bone Graft.

E D O'Sullivan¹, R K Battle², S Zahra³

¹Department of Renal Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons

|February 16, 2017

Summary

This summary is machine-generated.

Patients can develop anti-HLA antibodies after orthopedic surgery involving bone grafts, even with small grafts. This unexpected allosensitization can impact organ transplant eligibility.

Area of Science:

Immunology
Transplantation Science
Orthopedic Surgery

Background:

Keywords:

alloantigen clinical research/practice histocompatibility major histocompatibility complex (MHC)panel reactive antibody (PRA)tissue (nonvascularized) transplantation

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Patients can develop donor-specific anti-HLA antibodies from prior exposures like transplantation, pregnancy, or transfusions.
Allosensitization is a significant concern in organ transplantation, potentially leading to graft rejection.
Bone grafts are typically associated with allosensitization in massive trauma or malignancy cases, often confounded by blood transfusions.