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Related Experiment Videos

In vivo studies with fibre components.

E W Pomare, L C Hillman, S Peters

    Scandinavian Journal of Gastroenterology. Supplement
    |January 1, 1987
    PubMed
    Summary

    Dietary fiber impacts bile acid metabolism differently based on type. Highly fermentable pectin increases secondary bile acid formation, while cellulose decreases it, with lignin having no effect.

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    Area of Science:

    • Gastroenterology
    • Nutrition Science
    • Metabolic Research

    Background:

    • Limited human studies exist on dietary fiber's in vivo effects on bile acid metabolism.
    • Previous research shows varied results depending on fiber type and quantity consumed.

    Purpose of the Study:

    • To investigate the in vivo effects of specific dietary fiber components (pectin, cellulose, lignin) on bile acid metabolism in humans.
    • To determine the impact of these fibers on biliary lipids.

    Main Methods:

    • Normal volunteers consumed pectin, cellulose, or lignin for four weeks.
    • Bile acid metabolism and biliary lipids were monitored.

    Main Results:

    • Pectin, a highly fermentable fiber, increased secondary bile acid formation.
    • Cellulose, a partially fermentable fiber, decreased secondary bile acid formation.
    • Lignin showed no significant effect on bile acid metabolism.
    • No fiber component significantly altered biliary lipids in the short term.

    Conclusions:

    • The type of dietary fiber significantly influences bile acid metabolism in humans.
    • The net effect of mixed-fiber diets depends on the relative proportions of each fiber type.
    • Longer-term effects (beyond 4 weeks) of dietary fiber on bile acid metabolism and biliary lipids remain to be studied.

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