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Platelet alpha-adrenoceptor function and aging.

K Winther, O Naesh

    Thrombosis Research
    |June 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Aging reduces platelet alpha-adrenoceptor binding and affinity. However, older adults show increased platelet sensitivity to adrenaline, suggesting membrane changes unrelated to alpha-adrenoceptors.

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    Area of Science:

    • Cardiovascular Physiology
    • Gerontology
    • Pharmacology

    Background:

    • Platelet alpha-adrenoceptors play a role in hemostasis and thrombosis.
    • Aging is associated with altered adrenergic signaling and increased cardiovascular risk.

    Purpose of the Study:

    • To investigate the impact of aging on platelet alpha-adrenoceptor binding and function.
    • To correlate receptor characteristics with platelet aggregation response to adrenaline in young and old individuals.

    Main Methods:

    • Binding assays using 3H-dihydro-alpha-ergocryptine (3H-DHE) to measure alpha-adrenoceptor density and affinity.
    • In vitro assessment of cyclic adenosine monophosphate (cAMP) levels after noradrenaline stimulation.
    • Measurement of adrenaline-induced platelet aggregation.

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    Main Results:

    • Platelet 3H-DHE binding and affinity were significantly lower in older adults compared to younger individuals.
    • Noradrenaline induced a greater decrease in cAMP in platelets from older adults.
    • Platelet aggregation response to adrenaline was enhanced in the older group.

    Conclusions:

    • Aging is associated with reduced platelet alpha-adrenoceptor density and affinity.
    • Enhanced platelet sensitivity to adrenaline in older individuals is not due to increased alpha-adrenoceptor number or affinity.
    • Age-related changes in platelet membrane composition may underlie altered adrenergic responsiveness.