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[The effect of the alimentary factor on erythrocyte ATPase activity in ischemic heart disease patients]
Insights
Coronary heart disease (CHD) in men is linked to impaired ion-transport ATPase function and hyperlipoproteinemia (HLP). Diet therapy can help normalize lipid metabolism and ATPase activity in CHD patients.
Area of Science:
- Biochemistry
- Cardiology
- Human Physiology
Background:
- Functional disorders of ion-transport ATPases are observed in patients with coronary heart disease (CHD).
- The severity of ATPase activity impairment correlates with hyperlipoproteinemia (HLP) in CHD patients.
Purpose of the Study:
- To investigate the relationship between ion-transport ATPase activity, cation concentrations, and lipid metabolism in men with CHD.
- To evaluate the effects of anti-atherosclerotic dietotherapy on these parameters.
Main Methods:
- Assessed general ATPase, Mg-ATPase, and Na, K-ATPase activities.
- Measured cation concentrations (Mg2+, Na+) in plasma and erythrocytes.
- Analyzed lipid metabolism parameters and correlated them with ATPase activity and cation levels.
- Monitored changes after a course of anti-atherosclerotic dietotherapy.
Main Results:
- ATPase activity impairment (general, Mg-ATPase, Na, K-ATPase) correlated with HLP in CHD patients.
- Observed varied cation concentration changes in plasma and erythrocytes, not always correlating with HLP or ATPase activity.
- Found positive correlations between elevated serum Mg2+ and erythrocyte Na+ with hypercholesterolemia.
- Noted inverse correlations between decreased Mg2+, suppressed Mg-ATPase activity, and hypo-alpha-cholesterolemia.
Conclusions:
- Ion-transport ATPase dysfunction is a feature of CHD in men, linked to HLP.
- Dietary interventions show potential for normalizing lipid metabolism and improving ion-transport ATPase function in CHD patients.
Abstract:
Functional disorders in the ion-transport ATPase system were detected in young and middle-aged males suffering from coronary heart disease (CHD). The degree of the ATPase activity impairment (general ATPase, Mg-ATPase and Na, K-ATPase) correlated with hyperlipoproteinemia (HLP) which was revealed in CHD patients. Different direction of changes was observed in the concentrations of cations in plasma and erythrocytes, that, in some cases, could not be correlated with the degree of HLP and suppression of ion-transport ATPase activity. Positive correlation was observed with respect to increased concentration of Mg2+ in serum and Na+ in erythrocytes, and hypercholesterolemia, as well as with respect to decreased concentration of Mg2+, suppressed Mg-ATPase activity, and hypo-alpha-cholesterolemia. A significant tendency to normalization of parameters of lipid metabolism and lipid-dependent ion-transport ATPases was recorded in CHD patients after a course of the anti-atherosclerotic dietotherapy.