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Related Experiment Video

Updated: Mar 7, 2026

A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery
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A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery

Published on: May 20, 2016

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Cross-institutional knowledge-based planning (KBP) implementation and its performance comparison to Auto-Planning

Binbin Wu1, Martijn Kusters2, Martina Kunze-Busch2

  • 1Department of Radiation Medicine, MedStar Georgetown University Hospital, Washington, USA.

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
|February 17, 2017
PubMed
Summary

A shared knowledge-based planning (KBP) library demonstrated comparable plan quality to the Auto-Planning Engine (APE). This study confirms that cross-institutional KBP is feasible despite differing clinical protocols.

Keywords:
APEIMRTKBPOVH

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Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Computational Biology

Background:

  • Knowledge-based planning (KBP) utilizes institutional libraries for treatment plan optimization.
  • Cross-institutional application of KBP libraries is an emerging area for improving planning efficiency and consistency.

Purpose of the Study:

  • To evaluate the transferability of a plan library from Johns Hopkins University (JHU) to Radboud University Medical Center (RUMC) for oropharyngeal cancer treatment.
  • To compare the performance of cross-institutional KBP against the Auto-Planning Engine (APE).

Main Methods:

  • An overlap-volume histogram (OVH) KBP approach was employed, using a JHU-derived plan library to guide RUMC patient plans.
  • Protocol-specific planning parameters were derived from RUMC patients and applied to OVH-KBP and APE for plan generation.
  • Statistical comparison was performed using the Wilcoxon rank-sum test.

Main Results:

  • Both OVH-KBP and APE achieved comparable plan quality for planning target volumes (PTVs).
  • OVH-KBP resulted in a significant dose reduction to the spinal cord (5.1Gy, p=0.0001) compared to APE.
  • Dose distributions to other organs at risk were similar between the two methods.

Conclusions:

  • Cross-institutional KBP is feasible and yields comparable plan quality to APE.
  • Differences in institutional protocols can be managed to enable successful library sharing.
  • This approach holds potential for broader adoption and standardization in radiation oncology planning.