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Related Experiment Videos

Digoxin-like immunoreactive substance in pregnancy.

A R González, S J Phelps, E B Cochran

    American Journal of Obstetrics and Gynecology
    |September 1, 1987
    PubMed
    Summary

    Digoxin-like immunoreactive substances are not useful for predicting preeclampsia. Fetal levels are higher than maternal, suggesting the fetus as the source, but these substances don't significantly impact pregnancy plasma volume.

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    Area of Science:

    • Obstetrics and Gynecology
    • Perinatology
    • Endocrinology

    Background:

    • Preeclampsia is a serious pregnancy complication.
    • Digoxin-like immunoreactive substances (DLIS) are endogenous compounds with potential roles in cardiovascular regulation.
    • Their role in preeclampsia and pregnancy is not fully understood.

    Purpose of the Study:

    • To assess the predictive value of DLIS for preeclampsia.
    • To investigate the relationship between fetal and maternal DLIS levels.
    • To examine the association between DLIS and plasma volume in preeclampsia.

    Main Methods:

    • Serum DLIS concentrations were measured in normotensive and preeclamptic pregnant women.
    • Umbilical artery and vein blood samples were analyzed.
    • DLIS levels were correlated with gestational age, birth weight, and plasma volume.

    Main Results:

    • Detectable DLIS levels increased with gestational age, with 91% positive in the third trimester.
    • DLIS concentrations were lower in preeclamptic women compared to normotensive women (p < 0.005).
    • No significant difference in DLIS was found when matched for gestational age.
    • Umbilical DLIS levels were significantly higher than maternal levels (p < 0.001).
    • DLIS correlated with fetal gestational age and birth weight but poorly with plasma volume.

    Conclusions:

    • DLIS levels have minimal value in predicting preeclampsia.
    • The fetus is likely the source of DLIS during pregnancy.
    • DLIS may not significantly contribute to plasma volume expansion in pregnancy.

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