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System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
Published on: April 5, 2017
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Mycobacterium tuberculosis chorismate mutase: A potential target for TB
Manjulatha Khanapur1, Mallika Alvala2, Maddela Prabhakar1
1Department of Medicinal Chemistry, Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India.
Bioorganic & Medicinal Chemistry
|February 17, 2017
Summary
Mycobacterium tuberculosis chorismate mutase (MtbCM) is crucial for nutrient supply and pathogenesis. Targeting MtbCM offers a promising strategy for developing new anti-tubercular agents due to its unique structure and function.
Area of Science:
- Biochemistry
- Molecular Biology
- Drug Discovery
Background:
- Mycobacterium tuberculosis chorismate mutase (MtbCM) is essential for synthesizing aromatic amino acids via the shikimate pathway.
- The secretory MtbCM, encoded by Rv1885c, is implicated in tuberculosis pathogenesis.
- Chorismate mutase is present in various organisms but absent in humans, making it an attractive drug target.
Purpose of the Study:
- To review recent advancements in the structure, function, and inhibition of MtbCM.
- To highlight MtbCM as a potential target for novel anti-tubercular drug development.
Main Methods:
- Literature review focusing on MtbCM structure, function, and inhibition.
- Analysis of MtbCM's role in Mycobacterium tuberculosis.
Main Results:
- MtbCM catalyzes the conversion of chorismate to prephenate, essential for phenylalanine and tyrosine biosynthesis.
- Inhibiting MtbCM could disrupt nutrient acquisition in M. tuberculosis.
- The unique characteristics of MtbCM present opportunities for selective drug design.
Conclusions:
- Understanding MtbCM's structure and function is key to designing effective inhibitors.
- Targeting MtbCM holds potential for developing new anti-tubercular therapies.
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