Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

2.3K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.3K
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

1.3K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.3K
Neural Regulation01:37

Neural Regulation

43.9K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.9K
Lysosomal Hydrolases01:22

Lysosomal Hydrolases

4.7K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protective Effect of Cordyceps militaris Extract Against Cigarette Smoke Extract Induced Neurodegeneration in Zebrafish Model.

Neurotoxicity research·2026
Same author

Assessment of Hippocampal, Prefrontal Cortical, and Striatal Dopaminergic Circuitry Underlying Altered Social Behavior in Diabetes.

Molecular neurobiology·2026
Same author

Gastrointestinal perforation in general oncology, metastatic colorectal cancer, and metastatic melanoma population.

Medical oncology (Northwood, London, England)·2025
Same author

Sonic hedgehog signalling pathway contributes in age-related disorders and Alzheimer's disease.

Ageing research reviews·2024
Same author

Essential oil and nanocarrier-based formulations approaches for vaginal candidiasis.

Therapeutic delivery·2023
Same author

2D-QSAR, molecular docking and MD simulation based virtual screening of the herbal molecules against Alzheimer's disorder: an approach to predict CNS activity.

Journal of biomolecular structure & dynamics·2023

Related Experiment Video

Updated: Mar 7, 2026

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease
03:20

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease

Published on: September 22, 2023

2.4K

Gut microbiota: Implications in Parkinson's disease.

Arun Parashar1, Malairaman Udayabanu1

  • 1Jaypee University of Information Technology, Waknaghat, District- Solan, Himachal Pradesh, PIN-173234, India.

Parkinsonism & Related Disorders
|February 17, 2017
PubMed
Summary

The gut microbiome influences brain function and neurological conditions. This review explores the link between gut microbiota and Parkinson's disease pathology, examining if dysbiosis is a cause or effect.

Keywords:
AntibioticsFecal transplantGerm-freeGut microbiotaParkinson's diseaseProbiotics

More Related Videos

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
15:09

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

Published on: October 3, 2012

17.5K
Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
08:09

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Published on: January 7, 2014

8.0K

Related Experiment Videos

Last Updated: Mar 7, 2026

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease
03:20

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease

Published on: September 22, 2023

2.4K
The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
15:09

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

Published on: October 3, 2012

17.5K
Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
08:09

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Published on: January 7, 2014

8.0K

Area of Science:

  • Neuroscience
  • Microbiology
  • Gastroenterology

Background:

  • Gut microbiota (GM) impacts neurological functions including cognition, learning, and memory.
  • GM modulation affects brain development and behavior, and is linked to neurological disorders like Alzheimer's disease and Parkinson's disease (PD).
  • PD patients exhibit GM dysbiosis, but its causal role remains unclear.

Purpose of the Study:

  • To review and synthesize evidence connecting gut microbiota and Parkinson's disease pathology.
  • To explore the potential causal relationship between GM dysbiosis and PD development.
  • To consolidate direct and indirect evidence linking GM to PD.

Main Methods:

  • Literature review of studies on gut microbiota and neurological disorders.
  • Analysis of research investigating GM dysbiosis in Parkinson's disease.
  • Synthesis of evidence on the gut-brain axis in neurodegenerative diseases.

Main Results:

  • The gut microbiome plays a significant role in brain health and disease.
  • Evidence suggests a strong association between gut dysbiosis and Parkinson's disease.
  • The review highlights potential mechanisms linking gut health to PD pathology.

Conclusions:

  • Gut microbiota alterations are implicated in Parkinson's disease.
  • Further research is needed to determine if gut dysbiosis is a cause or consequence of PD.
  • Understanding the gut-brain axis is crucial for novel PD therapeutic strategies.