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Skeletal Muscle Neurovascular Coupling, Oxidative Capacity, and Microvascular Function with 'One Stop Shop' Near-infrared Spectroscopy
Published on: February 20, 2018
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Image-based modelling of skeletal muscle oxygenation.
B Zeller-Plumhoff1,2, T Roose2, G F Clough3
1Helmholtz-Zentrum für Material- und Küstenforschung, Geesthacht, Germany berit.zeller-plumhoff@hzg.de.
Journal of the Royal Society, Interface
|February 17, 2017
Summary
This review explores mathematical models of skeletal muscle oxygenation, integrating imaging and biological data. Understanding microvascular structure is key for diagnosing diseases affecting oxygen supply.
Area of Science:
- Physiology
- Biomedical Engineering
- Medical Imaging
Background:
- Adequate oxygen supply is crucial for skeletal muscle function, especially during exercise.
- Diseases often impair microvascular function and alter blood vessel network structures, impacting tissue oxygenation.
- Investigating microvascular structure's influence on oxygenation requires diverse methods like biological experiments, imaging, and mathematical modeling.
Purpose of the Study:
- To review current mathematical models of skeletal muscle oxygenation based on in vivo and ex vivo microvasculature imaging.
- To discuss suitable imaging systems and methods for capturing blood vessel networks.
- To inform the relationship between anatomical characteristics, health, and disease, providing a workflow for image-based modeling.
Main Methods:
- Review of existing mathematical models for skeletal muscle oxygenation.
- Discussion of imaging techniques for in vivo and ex vivo muscle microvasculature.
- Analysis of the association between microvascular anatomy and physiological states.
Main Results:
- Identified mathematical models of skeletal muscle oxygenation linked to microvascular imaging.
- Presented and contrasted various imaging systems for blood vessel network capture.
- Highlighted the connection between anatomical features and disease-related oxygenation changes.
Conclusions:
- Combining imaging and mathematical modeling offers a comprehensive approach to understanding skeletal muscle oxygenation.
- Image-based modeling provides a tool for analyzing microvascular function in health and disease.
- Future advancements in imaging and measurement techniques are needed to fully assess microvascular oxygen exchange capabilities.
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