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Supplemental Selenium May Decrease Ovarian Cancer Risk in African-American Women.

Paul D Terry1, Bo Qin2, Fabian Camacho3

  • 1Department of Medicine, Graduate School of Medicine, University of Tennessee Medical Center, Knoxville, TN; pdterry@utk.edu.

The Journal of Nutrition
|February 17, 2017
PubMed
Summary
This summary is machine-generated.

Supplemental selenium intake may lower ovarian cancer risk in African-American women. This study found a significant inverse association, particularly strong in smokers, suggesting a potential protective effect of selenium supplements.

Keywords:
African Americanantioxidantsdietovarian cancerwomen

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Area of Science:

  • Epidemiology
  • Nutritional Science
  • Oncology

Background:

  • Ovarian cancer has high mortality in African-American women.
  • Previous studies have not examined antioxidant intake and ovarian cancer risk in this population.
  • The African American Cancer Epidemiology Study (AACES) is a population-based case-control study.

Purpose of the Study:

  • To investigate the association between antioxidant intake and ovarian cancer risk.
  • Focus on African-American women due to high disease mortality.
  • Evaluate specific antioxidants: selenium, carotenoids, vitamin C, and vitamin E.

Main Methods:

  • Recruited 406 ovarian cancer cases and 632 controls of African-American descent.
  • Utilized multivariable logistic regression models.
  • Adjusted for numerous potential confounding factors including BMI, smoking, and family history.

Main Results:

  • Highest supplemental selenium intake (>20 μg/d) was associated with ~30% lower ovarian cancer risk (OR: 0.67; 95% CI: 0.46, 0.97).
  • This inverse association was stronger in current smokers (OR: 0.13; 95% CI: 0.04, 0.46).
  • No significant associations were found for dietary selenium, carotenoids, vitamin C, or vitamin E.

Conclusions:

  • Findings suggest a potential inverse association between supplemental selenium intake and ovarian cancer risk in African-American women.
  • This is the first study to explore antioxidant associations with ovarian cancer in this demographic.
  • Supplemental selenium may offer a protective effect, especially for smokers.