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Related Experiment Videos

Apudomas.

P H Nakano, R R Bloom, B C Brown

    The American Surgeon
    |September 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Apudomas, tumors producing active amines, were studied in 159 cases. While many apudomas can produce ectopic hormones, few exhibited hormone-related symptoms, with pancreatic islet cell tumors being an exception.

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    Area of Science:

    • Endocrinology
    • Oncology
    • Pathology

    Background:

    • Apudomas are neoplasms known for producing biologically active amines.
    • Recent advancements have significantly expanded knowledge of these tumors over the past 15 years.

    Purpose of the Study:

    • To report on the experience with apudomas over an 8-year period (1975-1983).
    • To analyze the types of apudomas and their associated hormone production and symptoms.

    Main Methods:

    • Retrospective analysis of 159 apudomas diagnosed at The Piedmont Hospital.
    • Categorization of tumors including oat cell carcinomas, carcinoid tumors, paragangliomas, pancreatic islet cell tumors, medullary thyroid carcinomas, pituitary adenoma, and pinealocytoma.

    Main Results:

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    • The study identified 159 tumors with potential for ectopic hormone production.
    • Oat cell carcinomas (112) rarely showed hormone symptoms (2%).
    • Carcinoid tumors (37) presented with symptoms but not classic carcinoid syndrome.
    • Pancreatic islet cell tumors were the only rare apudomas consistently linked to ectopic hormone production symptoms.

    Conclusions:

    • Most apudomas, including oat cell carcinomas and carcinoid tumors, do not frequently present with hormone-related symptoms.
    • Pancreatic islet cell tumors represent a significant exception, often exhibiting symptomatology related to ectopic hormone production.