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Ectopic lymphoid neogenesis in rheumatic autoimmune diseases
Michele Bombardieri1, Myles Lewis1, Costantino Pitzalis1
1Centre for Experimental Medicine and Rheumatology, John Vane Science Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Nature Reviews. Rheumatology
|February 17, 2017
Summary
Ectopic lymphoid-like structures (ELSs) in rheumatic autoimmune diseases are not fully understood. This review explores their formation, function, and potential as therapeutic targets in conditions like rheumatoid arthritis.
Area of Science:
- Rheumatology
- Immunology
- Pathology
Background:
- Ectopic lymphoid neogenesis is common in chronic rheumatic autoimmune diseases.
- The precise mechanisms and clinical significance of ectopic lymphoid-like structures (ELSs) remain unclear.
Purpose of the Study:
- To review current knowledge on ELS formation, function, and clinical relevance in rheumatic autoimmune diseases.
- To identify gaps in understanding and explore therapeutic potential.
Main Methods:
- Literature review of studies on ELSs in rheumatoid arthritis, Sjögren syndrome, systemic lupus erythematosus, and myositis.
- Analysis of mechanisms, phenotypes, and treatment responses related to ELSs.
Main Results:
- ELSs exhibit features of ectopic germinal centers and contribute to autoantibody production.
- ELSs appear to influence disease severity and response to disease-modifying antirheumatic drugs (DMARDs).
Conclusions:
- Understanding ELSs is crucial for comprehending autoimmunity perpetuation.
- Targeting ELSs may offer novel therapeutic strategies for rheumatic autoimmune diseases.
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