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Related Concept Videos

Chronic Obstructive Pulmonary Disease01:24

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COPD: Pathogenesis and Clinical Features01:20

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Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
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Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

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Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
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Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

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Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
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Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

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Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
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Ectopic fat accumulation in patients with COPD: an ECLIPSE substudy.

Mickaël Martin1, Natalie Almeras1, Jean-Pierre Després1

  • 1Research Centre, Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval, Québec, QC.

International Journal of Chronic Obstructive Pulmonary Disease
|February 17, 2017
PubMed
Summary
This summary is machine-generated.

Ectopic fat accumulation is more prevalent in Chronic Obstructive Pulmonary Disease (COPD). Increased visceral adipose tissue (VAT) and reduced muscle tissue (MT) attenuation are linked to comorbidities and poorer clinical outcomes in COPD patients.

Keywords:
abdominal adipositymetabolic syndromemuscleobesity

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Area of Science:

  • Pulmonary Medicine
  • Radiology
  • Metabolic Disease

Background:

  • Obesity is increasingly linked to COPD, yet the prevalence of ectopic fat accumulation and its impact on outcomes remain unclear.
  • The Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) substudy investigated ectopic fat in COPD patients.

Purpose of the Study:

  • To test the hypothesis that COPD is associated with increased ectopic fat accumulation.
  • To determine if ectopic fat accumulation correlates with COPD-related outcomes and comorbidities.

Main Methods:

  • Computed tomography (CT) scans from the ECLIPSE study were used to quantify ectopic fat, visceral adipose tissue (VAT) cross-sectional area (CSA), and muscle tissue (MT) attenuation at L2-L3.
  • Statistical analyses, including the Cochran-Armitage trend test and regression models, examined relationships between body composition indices and clinical outcomes (6-minute walking distance, exacerbation rate, quality of life, FEV1 decline) and comorbidities.

Main Results:

  • COPD patients exhibited increased VAT CSA and reduced MT attenuation (indicating more muscle fat infiltration) compared to controls.
  • While increased VAT was not linked to adverse outcomes, decreased MT attenuation and CSA were associated with lower 6-minute walking distance and accelerated FEV1 decline.
  • VAT accumulation correlated with a higher probability of diabetes and gastroesophageal reflux, whereas reduced MT attenuation predicted cardiovascular comorbidities.

Conclusions:

  • Ectopic fat accumulation, specifically increased VAT and muscle fat infiltration, is significantly elevated in COPD patients.
  • These body composition changes are associated with important clinical outcomes and comorbidities in COPD.