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The spectrum of psychosis in multiple sclerosis: a clinical case series

Thomas G Gilberthorpe1, Kara E O'Connell2, Alison Carolan1

  • 1Department of Liaison Psychiatry, South London and Maudsley NHS Foundation Trust, Maudsley Hospital, London, UK.

Neuropsychiatric Disease and Treatment
|February 17, 2017
PubMed

Insights

Psychosis is more common in multiple sclerosis (MS) than previously thought. Early diagnosis and treatment of psychosis in MS patients are crucial for improving medication adherence, disability, and quality of life.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Immunology

Background:

  • Psychosis is considered rare in multiple sclerosis (MS).
  • Recent studies indicate MS-associated psychosis prevalence is 2-3 times higher than in the general population.
  • Untreated psychosis negatively affects MS treatment adherence, disability, and quality of life.

Purpose of the Study:

  • To describe the spectrum of psychotic disorders in multiple sclerosis (MS).
  • To analyze demographic, clinical, and neuroimaging data of MS patients with psychosis.
  • To highlight diagnostic and treatment challenges of psychosis in MS.

Main Methods:

  • Retrospective case series.
  • Analysis of demographic, clinical, and neuroimaging data.
  • Case vignettes illustrating interventions.

Main Results:

  • Detailed description of the spectrum of psychotic disorders associated with MS.
  • Identification of diagnostic and treatment challenges.
  • Examples of clinical interventions provided.

Conclusions:

  • Psychosis in MS is more prevalent than previously reported.
  • Effective management requires addressing diagnostic and therapeutic complexities.
  • Case examples offer insights into managing this complex patient group.
Keywords:
cognitivedemyelinationmultiple sclerosisneuropsychiatricpsychosisschizophrenia-like

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