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Docetaxel Retinopathy: A Case Report.

Sylvia Nghiem-Buffet1, Salomon Yves Cohen2, Audrey Giocanti-Auregan3

  • 1Centre d'Imagerie et de Laser, Paris, France; Ophthalmology Department, Vision and Handicaps, Avicenne Hospital, Bobigny, France.

Case Reports in Ophthalmology
|February 17, 2017
PubMed
Summary
This summary is machine-generated.

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En-face optical coherence tomography (OCT) can detect macular edema (ME) in patients treated for breast cancer, even when fluorescein angiography (FA) shows no leakage. This imaging technique reveals a petaloid pattern indicative of inner retinal cysts.

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Oncology

Background:

  • Breast cancer treatment with docetaxel and tamoxifen can lead to ocular toxicity.
  • Macular edema (ME) is a potential side effect, but its detection can be challenging.
  • Fluorescein angiography (FA) may not always show leakage in drug-induced ME.

Observation:

  • A patient treated for breast cancer presented with bilateral visual loss.
  • Spectral-domain OCT revealed cystic spaces in the macula.
  • En-face OCT demonstrated a petaloid arrangement of inner retinal cysts, characteristic of ME.

Findings:

  • En-face OCT successfully identified macular edema characterized by inner retinal cysts.
  • The petaloid appearance on En-face OCT was observed despite negative findings on FA.
Keywords:
En-face OCTMacular edemaTamoxifenTaxanesToxic retinopathy

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  • This suggests En-face OCT is valuable for diagnosing ME when FA is inconclusive.

    • Implications:

    • En-face OCT offers a non-invasive method for detecting ME in patients undergoing specific cancer therapies.
    • The findings highlight the potential synergistic toxicity of docetaxel and tamoxifen on the macula.
    • Early detection of ME using En-face OCT may allow for timely intervention and management of visual disturbances.