Related Experiment Video
Updated: Mar 7, 2026
Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression
Published on: January 12, 2024
Docetaxel Retinopathy: A Case Report
Sylvia Nghiem-Buffet1, Salomon Yves Cohen2, Audrey Giocanti-Auregan3
1Centre d'Imagerie et de Laser, Paris, France; Ophthalmology Department, Vision and Handicaps, Avicenne Hospital, Bobigny, France.
Background:
To report the use of En-face optical coherence tomography (OCT) in a patient treated with docetaxel and tamoxifen for breast cancer for the detection of macular edema (ME) without evidence of leakage on fluorescein angiography (FA).
Case Presentation:
A 52-year-old woman treated for breast cancer presented with bilateral visual loss for 2 months. FA showed no significant leakage while spectral-domain OCT scans of both eyes showed foveolar and parafoveolar cystic spaces in a moderately thickened macula. En-face OCT segmented at the inner retina showed the petaloid arrangement of cystic cavities, comparable to a cystoid ME.
Conclusions:
The combined use of tamoxifen could have potentiated the toxic effect of docetaxel on the macula. En-face OCT images may reveal a petaloid aspect of the macula due to cysts in the inner retina segmentation, when FA shows no leakage.
