Nanomaterials for sample pretreatment prior to capillary electrophoretic analysis
Vojtech Adam1, Marketa Vaculovicova1
1Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, CZ-613 00 Brno, Czech Republic and Central European Institute of Technology, Brno University of Technology, Purkynova 123, CZ-612 00 Brno, Czech Republic. marketa.vaculovicova@mendelu.cz.
The Analyst
|February 17, 2017
Summary
Nanomaterials enhance capillary electrophoresis by improving sample preconcentration, purification, and extraction. Their large surface area boosts sensitivity, overcoming detection limits for better molecule analysis.
Area of Science:
- Analytical Chemistry
- Materials Science
Background:
- Nanomaterials offer diverse applications in analytical science, including sample pretreatment, separation, detection, and identification.
- Capillary electrophoresis (CE) is a powerful separation technique, but often suffers from limited detection sensitivity.
Purpose of the Study:
- To review the application of nanomaterials for sample pretreatment in capillary electrophoresis.
- To highlight the role of nanomaterials in enhancing purification, preconcentration, and extraction for CE analysis.
Main Methods:
- Review of literature on nanomaterial applications in sample pretreatment for CE.
- Focus on off-line and on-line coupling of nanomaterial-based pretreatment with CE.
Main Results:
- Nanomaterials, particularly nanoparticles, significantly improve sample preconcentration due to their large surface area.
- This preconcentration effectively addresses the limited concentration detection limits of CE.
Conclusions:
- Nanomaterials are a powerful tool for sample preconcentration in capillary electrophoresis.
- Utilizing nanomaterials overcomes CE sensitivity limitations, enabling more effective target molecule analysis.
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