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Updated: Mar 7, 2026

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
B-H functionalization of the monocarba-closo-dodecaborate anion by rhodium and iridium catalysis
Yunjun Shen1, Yani Pan1, Kang Zhang1
1Department of Chemistry, Zhejiang University, 310027 Hangzhou, P.R. China. duttwyler@zju.edu.cn.
Abstract:
The regioselective derivatization of the monocarba-closo-dodecaborate anion via catalytic B-H bond activation is reported. Amide directing groups in combination with rhodium and iridium catalysts allowed for the direct functionalization of cage boron vertices. Products comprising B-C, B-N and B-Cl bonds were synthesized. As a key intermediate of the B-H activation step, an iridium complex with a direct B-Ir interaction was isolated and fully characterized by spectroscopic methods as well as X-ray crystallography.
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