Post-translational modifications of FLOWERING LOCUS C modulate its activity
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Updated: Mar 7, 2026

Chromatin Immunoprecipitation Assay for the Identification of Arabidopsis Protein-DNA Interactions In Vivo
Published on: January 14, 2016
Jun Soo Kwak1, Ga Hyun Son1, Jong Tae Song2
1Department of Plant Science and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, Korea.
Abstract:
Flowering Locus C (FLC) is a key floral repressor that precisely controls flowering time. The role of FLC has been extensively studied at the transcriptional level using molecular biological and epigenetic approaches. However, how FLC functions and how its stability is controlled at the post-translational level are only beginning to be understood. Recent studies show that various post-translational modifications (PTMs) control the stability and activity of FLC. In this review, we focus on three types of PTMs that regulate FLC function: phosphorylation, ubiquitination, and sumoylation. This report should serve as a model to guide post-translational studies of other important floral regulators.
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