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Zein-based composites in biomedical applications.

Merve Demir1, Laura Ramos-Rivera1, Raquel Silva1

  • 1Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Erlangen, 91058, Germany.

Journal of Biomedical Materials Research. Part A
|February 17, 2017
PubMed
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Zein-based biomaterials, enhanced with inorganic fillers, show promise for tissue engineering and drug delivery due to improved mechanical and hydrophilic properties. These composites offer a suitable environment for cell growth.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Drug Delivery

Background:

  • Zein, a biocompatible and biodegradable polymer, is extensively researched for biomedical applications.
  • Low mechanical strength of pure zein limits its use; inorganic fillers are explored to enhance properties.
  • Inorganic phases improve zein's hydrophilicity, promoting cell interaction for tissue regeneration.

Purpose of the Study:

  • To review literature on zein and zein-based composite materials.
  • To focus on the combination of zein with inorganic fillers for tissue engineering and drug delivery.
  • To highlight fabrication techniques, applications, and future directions.

Main Methods:

  • Comprehensive literature review of zein-based composite materials.
Keywords:
bone tissue engineeringcompositesscaffoldszein

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  • Analysis of inorganic filler incorporation strategies.
  • Examination of fabrication techniques and application-specific performance.

    • Main Results:

    • Combining zein with inorganic compounds (hydroxyapatite, calcium phosphate, etc.) significantly enhances mechanical properties.
    • Inorganic fillers improve hydrophilic characteristics, creating a favorable microenvironment for cellular activities.
    • Zein composites demonstrate potential in tissue engineering scaffolds and drug delivery systems.

    Conclusions:

    • Zein-based composites offer a tunable platform for biomedical applications by integrating inorganic materials.
    • Further research into fabrication methods and specific applications can unlock the full potential of these biomaterials.
    • The synergistic effects of zein and inorganic fillers present promising avenues for advanced regenerative medicine and therapeutics.