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Functionalized calix[4]arenes as potential therapeutic agents.

Muhammad Moazzam Naseer1, Mukhtiar Ahmed1, Shahid Hameed1

  • 1Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan.

Chemical Biology & Drug Design
|February 17, 2017
PubMed
Summary
This summary is machine-generated.

Functionalized calixarenes show diverse biological activities, including antiviral and anticancer properties. This review highlights their synthesis and potential as drug candidates for developing new therapeutic agents.

Keywords:
biological activitycalixarenescone conformationfunctionalizationupper/lower rim/annulus

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Area of Science:

  • Supramolecular Chemistry
  • Medicinal Chemistry

Background:

  • Calixarenes are macrocyclic compounds with hydrophobic cavities capable of hosting molecules.
  • These macrocycles are emerging as promising platforms for designing biologically active compounds.

Purpose of the Study:

  • To review synthetic strategies for functionalized calixarenes.
  • To discuss the biological potential of these compounds, focusing on recent advancements.

Main Methods:

  • Literature review of synthetic approaches for functionalized calixarenes.
  • Analysis of reported biological activities (antiviral, antibacterial, antifungal, anticancer).

Main Results:

  • Functionalized calixarenes exhibit a broad spectrum of biological activities.
  • Recent studies demonstrate their potential in pharmaceutical and medicinal chemistry.

Conclusions:

  • Functionalized calixarenes are versatile scaffolds for developing novel therapeutic agents.
  • Further research can accelerate the development of clinically viable drugs based on these macrocycles.