Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.4K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.4K
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

662
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
662

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Artificial intelligence-driven data expansion for the validation of spinopelvic parameter correlations in asymptomatic subjects.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026
Same author

Beyond sacral slope: a new quantitative paradigm for Roussouly classification.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026
Same author

Optimized Centrifugation and Activation Protocol for the Preparation of Plasma Rich in Growth Factors in Pigs.

Biomedicines·2026
Same author

Clinical and radiological evaluation of cortical bone trajectory screw placement using patient-specific 3D templates: a multicentric prospective study.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026
Same author

2025 ICM: Nutrition.

The Journal of arthroplasty·2025
Same author

2025 ICM: Samples for Culture.

The Journal of arthroplasty·2025

Related Experiment Video

Updated: Mar 7, 2026

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.
05:46

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.

Published on: February 14, 2021

4.2K

Are Modic type 2 disc changes associated with low-grade infections? A pilot study.

Lorenzo Drago1,2, Carlo L Romanò1, Riccardo Cecchinato1

  • 1Galeazzi Orthopedic Institute IRCCS, Milan, Italy.

Journal of Neurosurgical Sciences
|February 17, 2017
PubMed
Summary

Intraoperative cultures revealed a higher prevalence of low-virulent bacteria in patients with Modic 2 changes compared to those without, suggesting a potential link between these spinal changes and bacterial presence.

More Related Videos

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
06:23

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

5.5K
Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration
06:22

Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration

Published on: July 8, 2021

2.6K

Related Experiment Videos

Last Updated: Mar 7, 2026

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.
05:46

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.

Published on: February 14, 2021

4.2K
Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
06:23

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

5.5K
Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration
06:22

Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration

Published on: July 8, 2021

2.6K

Area of Science:

  • Spinal imaging and diagnostics
  • Microbiology in orthopedics

Background:

  • Modic 2 changes are common findings in low-back pain patients undergoing surgery.
  • The etiology of Modic 2 changes remains incompletely understood.
  • Investigating potential infectious links is crucial for understanding spinal pathologies.

Purpose of the Study:

  • To compare intraoperative cultures in patients with and without Modic 2 changes.
  • To determine if Modic 2 changes are associated with the presence of bacteria.

Main Methods:

  • Comparative study of 16 patients with Modic 2 changes and 23 patients without Modic signs.
  • Standardized preoperative laboratory tests and intraoperative tissue cultures were performed.

Main Results:

  • No significant differences in preoperative laboratory tests between groups.
  • Intraoperative cultures were positive in 37.5% of Modic 2 patients versus 4.3% of non-Modic patients (P=0.012).

Conclusions:

  • Findings support the hypothesis that low-virulent bacteria may be associated with some Modic 2 changes.
  • Further research with larger cohorts is warranted to confirm this association.