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Expression and clinical significance of pepsinogen C in uveal melanomas
M L Alvarez1, L O Gonzalez, J J Barbon
1Department of Ophthalmology, Hospital Alvarez-Buylla, Mieres, Asturias - Spain.
Purpose:
we investigated by immunohistochemistry the pepsinogen C (pepC) expression in uveal melanomas and analyzed the possible relationship to clinicopathological parameters and prognostic significance.
Methods:
We studied 22 patients who had undergone enucleation of the eyeball or local tumor resection for uveal melanoma. The specimens were immunostained for pepC on formalin-fixed, paraffin-embedded sections. Sex, age, tumor location, histological type, local invasion, postoperative treatment and metastasis were evaluated.
Results:
Eleven tumors (50%) were positive for pepsinogen C. The percentage of pepC-positive tumors was significantly higher in uveal melanomas with scleral invasion than in those without scleral invasion (p<0.01). PepC expression was significantly associated with a shortened overall survival (p<0.05).
Conclusions:
Our results show that pepsinogen C may be expressed by uveal melanoma and suggest that this protein could be considered as a new, unfavorable prognostic factor in these tumors. (Int J Biol Markers 2004; 19: 240-4).
