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A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9
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Cysteine proteases in atherosclerosis.

Tommy Weiss-Sadan1, Israel Gotsman2, Galia Blum1

  • 1The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, Hebrew University, Jerusalem, Israel.

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|February 17, 2017
PubMed
Summary
This summary is machine-generated.

Cysteine cathepsins play a key role in atherosclerosis development by affecting lipid metabolism, inflammation, and apoptosis. Understanding these proteases offers new avenues for cardiovascular disease diagnostics and therapeutics.

Keywords:
activity-based probesatherosclerosisautophagycathepsinscholesterolmetabolismvascular inflammation

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Area of Science:

  • Biochemistry
  • Cardiovascular Biology
  • Molecular Medicine

Background:

  • Atherosclerosis, a precursor to cardiovascular diseases like myocardial infarction and stroke, involves lipid and inflammatory cell retention in the vascular endothelium.
  • Vascular lesions initially harmless can progress due to chronic inflammation and remodeling, leading to arterial wall damage and thrombotic events.

Purpose of the Study:

  • To elucidate the function of cysteine cathepsins in cellular processes dysregulated in atherosclerosis.
  • To explore the contribution of cathepsins to arterial remodeling and atherogenesis.
  • To review advancements in protease molecular imaging for cardiovascular event prediction.

Main Methods:

  • Review of human tissue evidence and preclinical animal models.
  • Analysis of the role of cysteine cathepsins in lipid metabolism, inflammation, and apoptosis.
  • Exploration of protease molecular imaging techniques.

Main Results:

  • Cysteine cathepsins are integral to the development and progression of vascular lesions in atherosclerosis.
  • Dysfunctional cellular processes including lipid metabolism, inflammation, and apoptosis are influenced by cathepsins.
  • Protease molecular imaging presents potential as a diagnostic marker for cardiovascular events.

Conclusions:

  • Targeting cysteine cathepsins presents therapeutic opportunities for atherosclerosis.
  • Advanced molecular imaging of proteases may serve as a surrogate marker for identifying future cardiovascular events.