Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Dual-Pronged Hafnia-Prodrug-Lipid Nanoplatform Coupling Radiosensitization and DNA Homologous Recombination Inhibition.

ACS nano medicine·2026
Same author

Financial and legal empowerment in women's reproductive health decision-making in rural China and Pakistan: A qualitative study.

African journal of reproductive health·2026
Same author

Enflonsia (clesrovimab) and the future of RSV lower respiratory tract disease prevention in neonates.

Annals of medicine and surgery (2012)·2026
Same author

Midfoot Skeletal Tuberculosis Managed With Single-Stage Tarsometatarsal and Naviculocuneiform Arthrodesis and Antitubercular Therapy.

Foot & ankle orthopaedics·2026
Same author

A Patient-Clinician Co-Designed Infographic for Diabetic Ketoacidosis Education in Type 1 Diabetes.

Canadian journal of diabetes·2026
Same author

Study protocol for a mobile app that delivers peer-led mental health support to adults with type 1 diabetes: The REACHOUT randomized wait-list controlled trial.

Contemporary clinical trials·2026

Related Experiment Video

Updated: Mar 7, 2026

Techniques for Processing Eyes Implanted With a Retinal Prosthesis for Localized Histopathological Analysis
12:01

Techniques for Processing Eyes Implanted With a Retinal Prosthesis for Localized Histopathological Analysis

Published on: August 2, 2013

20.4K

Real-Time Monitoring of Post-Surgical and Post-Traumatic Eye Injuries Using Multilayered Electrical Biosensor Chip.

Muhammad S Khan, Santosh K Misra, Aaron S Schwartz-Duval

  • 1Department of Surgery, University of Illinois College of Medicine , Urbana, Illinois 61801, United States.

ACS Applied Materials & Interfaces
|February 17, 2017
PubMed
Summary
This summary is machine-generated.

A new ocular biosensor device offers early detection of eye injuries by quantitatively measuring ascorbic acid (AA) in tears and aqueous humor. This point-of-care tool addresses the need for reliable monitoring of ocular conditions.

Keywords:
aqueous humorascorbate oxidaseascorbic acidbiosensoreye injuryglaucomagraphenepoint-of-caretear film

More Related Videos

Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram
06:12

Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram

Published on: March 13, 2018

11.2K
Techniques for Processing Eyes Implanted with a Retinal Prosthesis for Localized Histopathological Analysis: Part 2 Epiretinal Implants with Retinal Tacks
10:00

Techniques for Processing Eyes Implanted with a Retinal Prosthesis for Localized Histopathological Analysis: Part 2 Epiretinal Implants with Retinal Tacks

Published on: February 14, 2015

12.8K

Related Experiment Videos

Last Updated: Mar 7, 2026

Techniques for Processing Eyes Implanted With a Retinal Prosthesis for Localized Histopathological Analysis
12:01

Techniques for Processing Eyes Implanted With a Retinal Prosthesis for Localized Histopathological Analysis

Published on: August 2, 2013

20.4K
Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram
06:12

Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram

Published on: March 13, 2018

11.2K
Techniques for Processing Eyes Implanted with a Retinal Prosthesis for Localized Histopathological Analysis: Part 2 Epiretinal Implants with Retinal Tacks
10:00

Techniques for Processing Eyes Implanted with a Retinal Prosthesis for Localized Histopathological Analysis: Part 2 Epiretinal Implants with Retinal Tacks

Published on: February 14, 2015

12.8K

Area of Science:

  • Biomedical Engineering
  • Ophthalmology
  • Analytical Chemistry

Background:

  • Current methods for detecting ocular injuries like bleb leaks lack quantitative accuracy and early detection capabilities.
  • There are no FDA-approved devices for point-of-care measurement of ascorbic acid (AA) in tear film (TF) and aqueous humor (AH).

Purpose of the Study:

  • To develop a novel, disposable, paper-based point-of-care (POC) ocular biosensor for quantitative assessment of ocular injury.
  • To evaluate the integrity of the anterior eye surface by measuring AA concentrations in TF and AH.

Main Methods:

  • Development of a POC ocular biosensor strip using a grafted poly(styrene)-block-poly(acrylic acid) (PS-b-PAA) and graphene platelet composite.
  • Utilized a contour-based microelectrode design (CBμE) for a highly sensitive electrochemical immunosensing platform.
  • Collected clinical samples from subjects undergoing therapeutic anterior chamber paracentesis.

Main Results:

  • The developed biosensor successfully measured AA concentrations in small-volume clinical samples, including tear fluid.
  • The device provides quantitative, easy-to-read results on an electronic screen, demonstrating reliability.
  • The novel engineering approach enables sensitive detection for ocular diagnostics.

Conclusions:

  • The proposed ocular biosensor device represents a significant advancement in the early monitoring of post-traumatic and post-surgical ocular injuries.
  • This POC quantitative assay addresses a critical unmet clinical need for objective assessment of anterior eye surface integrity.
  • The disposable, paper-based biosensor offers a reliable and efficient method for measuring AA levels in ocular fluids.