Related Experiment Video

Updated: Mar 7, 2026

Iris Fixation via External Pentagram Suturing
05:22

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

1.9K

Long-Term Clinical Course in Eyes With Peters Anomaly

Haruna Yoshikawa1, Chie Sotozono, Yoko Ikeda

  • 1Departments of *Ophthalmology; and †Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Cornea
|February 17, 2017
PubMed

Insights

Peters anomaly (PA) can resolve naturally, with corneal opacity decreasing over time in some infants. Early, intensive amblyopia treatment is crucial for favorable visual outcomes in unilateral PA cases without glaucoma.

Area of Science:

  • Ophthalmology
  • Pediatric Ophthalmology
  • Genetics

Background:

  • Peters anomaly (PA) is a leading cause of congenital corneal opacity.
  • Understanding the natural history of PA is essential for guiding clinical management.
  • Long-term outcomes for PA patients not undergoing corneal transplantation are not well-documented.

Purpose of the Study:

  • To investigate the long-term clinical course and visual outcomes of infants with Peters anomaly.
  • To evaluate patients with PA who were managed conservatively without keratoplasty.

Main Methods:

  • Retrospective study of 9 infants (15 eyes) with PA presenting before 5 months of age.
  • Follow-up duration exceeded 6 years post-initial presentation.
  • Key data collected included visual acuity, intraocular pressure (IOP), glaucoma presence, and corneal opacity changes.

Main Results:

  • Congenital glaucoma was present in 13 eyes of 7 patients.
  • Corneal opacity showed gradual decrease in 4 eyes.
  • Improved visual acuity was observed in a unilateral case with intensive amblyopia treatment and decreasing opacity.

Conclusions:

  • Natural resolution of corneal opacity is possible in some cases of Peters anomaly.
  • Aggressive amblyopia therapy is critical for achieving good vision in unilateral PA without elevated IOP or corneal enlargement.
Abstract

More Related Videos

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.6K
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

2.0K

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.6K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.5K
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
10.4K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K