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Ion Elevators and Escalators in Multilevel Structures for Lossless Ion Manipulations.

Yehia M Ibrahim1, Ahmed M Hamid1, Jonathan T Cox1

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New ion elevator and escalator components enable lossless ion manipulation in multi-level structures. These advancements enhance ion mobility spectrometry (IMS) devices for more complex applications.

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Area of Science:

  • Analytical Chemistry
  • Physical Chemistry

Background:

  • Structures for Lossless Ion Manipulations (SLIM) enable precise control of ion trajectories.
  • Developing multi-level SLIM devices requires efficient methods for vertical ion transport.

Purpose of the Study:

  • To design and evaluate novel ion "elevator" and "escalator" components for vertical ion transport in SLIM.
  • To assess the performance of these components in terms of ion transmission efficiency and resolution.

Main Methods:

  • Ion motion simulations guided the design of elevator and escalator components.
  • Ion current measurements and ion mobility (IM) spectrometry were used for performance evaluation.
  • The ion elevator was integrated into a SLIM coupled to a QTOF mass spectrometer.

Main Results:

  • The ion elevator successfully bridged a 4 mm gap with lossless transmission for ions in the m/z 600-2700 range.
  • Similar mass spectra were obtained for ions transported by the elevator compared to linear motion.
  • The ion escalator, using traveling waves, transported ions between levels with no significant loss of ions or IM resolution.

Conclusions:

  • Ion elevator and escalator components enable efficient, lossless vertical ion transport in SLIM.
  • These components facilitate the development of multi-level SLIM devices with longer ion mobility path lengths and increased complexity.
  • Future applications include SLIM devices with varied operational conditions on different levels.