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Chitosan-Recombinamer Layer-by-Layer Coatings for Multifunctional Implants.

Jeevan Prasaad Govindharajulu1, Xi Chen2, Yuping Li3

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International Journal of Molecular Sciences
|February 18, 2017
PubMed
Summary

Dental implants face challenges with biofilm formation and poor bone integration. A new chitosan/P-HAP coating on titanium surfaces shows promise for enhanced osseointegration and reduced bacterial adhesion, improving implant success.

Keywords:
chitosanelastin-like recombinamersimplantlayer-by-layertitanium

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Area of Science:

  • Biomaterials Science
  • Dental Implantology
  • Tissue Engineering

Background:

  • Dental implants commonly face clinical issues like peri-implantitis (biofilm formation) and lack of osseointegration (inadequate bone formation).
  • Chitosan exhibits beneficial biocompatibility and antibacterial properties.
  • Osseo-inductive recombinant elastin-like biopolymer (P-HAP) containing a statherin-derived peptide promotes biomineralization and osteoblast differentiation.

Purpose of the Study:

  • To develop and characterize a novel chitosan/P-HAP bi-layered coating on titanium dental implant surfaces.
  • To evaluate the coating's efficacy in promoting osseointegration and preventing bacterial colonization.

Main Methods:

  • Layer-by-layer (LbL) assembly technique was employed to create chitosan/P-HAP bi-layers on titanium.
  • Surface characterization included water contact angle measurements, diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS), X-ray photoelectron spectroscopy (XPS), and atomic force microscopy (AFM).
  • Biomineralization, pre-osteoblastic cell response, and antibacterial activity against Streptococcus gordonii were assessed.

Main Results:

  • Successful fabrication of chitosan/P-HAP LbL assembly on titanium surfaces was confirmed through various characterization techniques.
  • The modified surfaces demonstrated enhanced biomineralization.
  • Appropriate mouse pre-osteoblastic cell response and significant antibacterial activity against Streptococcus gordonii were observed.

Conclusions:

  • The developed chitosan/P-HAP bi-layered coating effectively enhances osseointegration and provides antibacterial properties for dental implants.
  • LbL assembly is a viable technique for creating functionalized implant surfaces to address key clinical challenges.
  • This biomaterial approach holds significant potential for improving dental implant outcomes.