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Cell-Penetrating Peptides: From Basic Research to Clinics.

Giulia Guidotti1, Liliana Brambilla1, Daniela Rossi1

  • 1Laboratory for Research on Neurodegenerative Disorders, IRCCS Maugeri Clinical and Scientific Institutes SpA SB, Via Maugeri 10, 27100 Pavia, Italy.

Trends in Pharmacological Sciences
|February 18, 2017
PubMed
Summary
This summary is machine-generated.

Cell-penetrating peptides (CPPs) enhance drug delivery across biological barriers, improving therapeutic efficacy. These peptides enable targeted intracellular drug delivery, opening new avenues for treating diseases effectively.

Keywords:
cell-penetrating peptidesclinical trialsinternalizationtherapy

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Area of Science:

  • Biochemistry
  • Pharmacology
  • Biotechnology

Background:

  • Systemic drug distribution is often limited by cell and tissue barriers, reducing the therapeutic value of many molecules.
  • Low biomembrane permeability hinders the effective delivery of therapeutics to target sites within cells.

Purpose of the Study:

  • To explore the potential of cell-penetrating peptides (CPPs) to overcome drug delivery challenges.
  • To evaluate CPPs as a strategy for enhancing drug concentrations in hard-to-access areas.
  • To assess the therapeutic implications of CPP-mediated intracellular drug delivery.

Main Methods:

  • Utilized cell-penetrating peptides (CPPs) to transport biologically active conjugates (cargoes) into cells.
  • Conducted preclinical evaluations of CPP-derived therapeutics in various disease models.
  • Monitored the distribution and efficacy of CPP-delivered therapeutics.

Main Results:

  • CPPs demonstrated the ability to transport a wide range of cargoes into cells.
  • Preclinical studies showed promising results for CPP-derived therapeutics in multiple disease models.
  • Some CPP-based therapies have advanced to clinical trials, indicating significant potential.

Conclusions:

  • Cell-penetrating peptides (CPPs) offer a promising strategy to improve drug delivery and overcome biological barriers.
  • CPP-mediated delivery facilitates targeted intracellular drug concentrations, enhancing therapeutic outcomes.
  • The development of CPP-based therapies holds potential for well-tolerated, effective treatments for intracellular targets.