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Proliferative verrucous leukoplakia: diagnosis, management and current advances
Diogo Lenzi Capella1, Jussara Maria Gonçalves1, Adelino António Artur Abrantes1
1Universidade Federal de Santa Catarina (UFSC), Programa de Pós-graduação em Odontologia, Florianopolis, SC, Brazil.
Introduction:
Proliferative verrucous leukoplakia is a multifocal and progressive lesion of the oral mucosa, with unknown etiology, and commonly resistant to all therapy attempts with frequent recurrences. It is characterized by a high rate of oral squamous cell carcinoma and verrucou carcinoma transformations.
Objective:
To analyze the studies about Proliferative verrucous leukoplakia and develop a concise update.
Methods:
A Pubmed search identifying studies (laboratory research, case series and reviews of literature) that examined patients with Proliferative verrucous leukoplakia was realized.
Results:
There are not enough studies about Proliferative verrucous leukoplakia in the literature. The few found studies not present a consensus about its etiology and diagnosis criteria. Although several treatment strategies have been proposed, most of them still show a high recurrence rate.
Conclusion:
More research about Proliferative verrucous leukoplakia is necessary to understand and treat this disease.
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