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Published on: April 2, 2021
Association between VEGF polymorphisms (-460 T/C and +936 C/T) and retinopathy of prematurity risk: A meta-analysis
Swati Shukla1, Manzoor Ahmad Malik1, Parijat Chandra2
1Department of Ocular Biochemistry, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi 110029, India.
Purpose:
Vascular endothelial growth factor (VEGF) contributes to the development of retinopathy of prematurity (ROP). A number of studies investigated the association of ROP with VEGF -460 T/C and +936 C/T polymorphisms but the results were conflicting. In order to derive a more precise estimation of the associations, we performed a meta-analysis of the relationship between VEGF -460 T/C and +936 C/T polymorphisms with ROP in all published studies.
Methods:
A literature search was performed systematically using electronic databases. Published literature from PubMed and other databases was retrieved. The odds ratio (OR) with 95% confidence interval (CI) was used to estimate the pooled effect. Each -460 T/C and +936 C/T polymorphism included four case-control studies including case/control 249/308 and 179/250 respectively.
Results:
Through literature search, we found that both VEGF -460 T/C and +936 C/T polymorphisms were not associated with ROP risk at allelic, co-dominant, dominant and recessive models.
Conclusions:
This meta-analysis suggests that the VEGF -460 T/C and +936 C/T polymorphism might contribute to genetic susceptibility of ROP. The association between VEGF -460 T/C and +936 C/T polymorphism and ROP risk awaits further investigation.
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