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Related Experiment Video

Updated: Mar 7, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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B lymphocytes in renal interstitial fibrosis.

Fengge Zhu1, Xueyuan Bai2, Xiangmei Chen3

  • 1Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, China.

Journal of Cell Communication and Signaling
|February 18, 2017
PubMed
Summary

Fibrosis involves excessive extracellular matrix deposition, damaging organs. This review highlights the emerging role of B cells in fibrosis, suggesting potential therapeutic targets for future treatments.

Keywords:
B cellB lymphocyteInflammationRenal interstitial fibrosis

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Area of Science:

  • Immunology
  • Pathology
  • Cell Biology

Background:

  • Fibrosis is characterized by excessive extracellular matrix (ECM) deposition, leading to organ damage and dysfunction.
  • Fibrosis affects multiple organs, including the kidney, lung, liver, heart, and skin, suggesting common underlying mechanisms.
  • Renal interstitial fibrosis is a complex process involving intricate molecular signaling and cellular interactions.

Purpose of the Study:

  • To review recent research on the role of B cells in fibrosis.
  • To explore the mechanisms by which B cells influence fibrotic processes.
  • To provide insights into developing future fibrosis therapeutics targeting B cells.

Main Methods:

  • Literature review of recent research findings.
  • Analysis of B cell involvement in fibrotic pathways.
  • Synthesis of information on B cell-mediated cytokine production and cellular interactions.

Main Results:

  • B cells are identified as important emerging players in renal interstitial fibrosis.
  • B cells can influence fibrosis through the production of cytokines.
  • B cells interact with other key cells in fibrosis, such as fibroblasts, macrophages, and T cells.

Conclusions:

  • B cells play a significant role in the pathogenesis of fibrosis.
  • Understanding B cell functions in fibrosis opens new avenues for therapeutic development.
  • Targeting B cells may offer a promising strategy for future anti-fibrotic therapies.