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Updated: Mar 7, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Pemphigoid-in Identical Diabetic Twins.

T P Thankappan, M I Joy

    Indian Journal of Dermatology, Venereology and Leprology
    |February 18, 2017
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    Summary
    This summary is machine-generated.

    Identical twin sisters developed bullous pemphigoid simultaneously. Both sisters also had diabetes mellitus, suggesting a potential genetic or environmental link in this rare autoimmune blistering disease.

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    Area of Science:

    • Dermatology
    • Genetics
    • Endocrinology

    Background:

    • Bullous pemphigoid is a rare autoimmune blistering disease.
    • Diabetes mellitus is a common metabolic disorder.
    • Identical twins share nearly all their genetic material.

    Observation:

    • This report details a unique case of identical twin sisters.
    • Both sisters presented with bullous pemphigoid.
    • Both sisters also had a diagnosis of diabetes mellitus.

    Findings:

    • The simultaneous onset of bullous pemphigoid in identical twins is highly unusual.
    • The co-occurrence with diabetes mellitus in both sisters may indicate shared genetic predispositions or environmental triggers.
    • This case highlights a potential association between these conditions.

    Implications:

    • Further research may elucidate shared genetic factors or environmental influences contributing to bullous pemphigoid.
    • Understanding these associations could lead to improved risk assessment and early detection strategies.
    • This case contributes to the understanding of rare disease co-occurrence in genetically identical individuals.