Related Experiment Video

Updated: Aug 6, 2026

Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease
10:32

Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease

Published on: June 17, 2013

56.4K

Motor phenotype is not associated with vascular dysfunction in symptomatic Huntington's disease transgenic R6/2 (160

A Di Pardo1, A Carrizzo1, A Damato1

  • 1IRCCS Neuromed, Pozzilli (Italy).

Scientific Reports
|February 18, 2017
PubMed

Insights

Huntington's disease (HD) does not cause vascular dysfunction in mice, despite cardiac issues. This study found no link between motor deficits and vascular problems in the R6/2 model.

Area of Science:

  • Neuroscience
  • Cardiovascular Science
  • Genetics

Background:

  • Huntington's disease (HD) is primarily neurological but shows peripheral pathology, including cardiac defects.
  • Vascular dysfunction is often associated with cardiac impairment, but its presence in HD remains unclear.

Purpose of the Study:

  • To investigate vascular system function in the R6/2 mouse model of Huntington's disease.
  • To determine if cardiac dysfunction in HD correlates with peripheral vascular dysfunction.

Main Methods:

  • Functional characterization of the vascular system using wire myography in symptomatic R6/2 mice and wild-type littermates.
  • Assessment of disease stage through behavioral tests (rotarod, horizontal ladder task).

Main Results:

  • No detectable vascular dysfunction was observed in symptomatic R6/2 mice.
  • No correlation was found between the motor phenotype and vascular reactivity.

Conclusions:

  • The R6/2 mouse model does not exhibit peripheral vascular dysfunction, even with cardiac pathology.
  • Vascular integrity appears unaffected in this HD mouse model, irrespective of motor impairment.

More Related Videos

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

8.9K
Low-Cost Gait Analysis for Behavioral Phenotyping of Mouse Models of Neuromuscular Disease05:53

Low-Cost Gait Analysis for Behavioral Phenotyping of Mouse Models of Neuromuscular Disease

Published on: July 18, 2019

17.9K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...