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Noble Gases02:54

Noble Gases

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The elements in group 18 are noble gases (helium, neon, argon, krypton, xenon, and radon). They earned the name “noble” because they were assumed to be nonreactive since they have filled valence shells. In 1962, Dr. Neil Bartlett at the University of British Columbia proved this assumption to be false.
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Refrigerators and Heat Pumps01:07

Refrigerators and Heat Pumps

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Refrigerators or heat pumps are heat engines operating in a reverse direction. For a refrigerator, the focus is on removing heat from a specific area, whereas, for a heat pump, the focus is on dumping heat into one particular area. A refrigerator (or heat pump) absorbs heat Qc from the cold reservoir at Kelvin temperature Tc and discards heat Qh to the hot reservoir at Kelvin temperature Th, while work W is done on the engine’s working substance.
A household refrigerator removes heat from...
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Global Climate Change01:50

Global Climate Change

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Throughout its ~4.5 billion year history, the Earth has experienced periods of warming and cooling. However, the current drastic increase in global temperatures is well outside of the Earth’s cyclic norms, and evidence for human-caused global climate change is compelling. Paleoclimatology, the study of ancient climate conditions, provides ample evidence for human-caused global climate change by comparing recent conditions with those in the past.
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Radical Halogenation: Thermodynamics01:34

Radical Halogenation: Thermodynamics

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The thermodynamic favorability of a reaction is determined by the change in Gibbs free energy (ΔG). ΔG has two components- enthalpy (ΔH) and entropy (ΔS). The entropy component is negligible for alkane halogenation because the number of reactants and product molecules are equal. In this case, the ΔG is governed only by the enthalpy component. The most crucial factor that determines ΔH is the strength of the bonds. ΔH can be determined by comparing the energy...
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Comparing Intermolecular Forces: Melting Point, Boiling Point, and Miscibility02:34

Comparing Intermolecular Forces: Melting Point, Boiling Point, and Miscibility

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Intermolecular forces are attractive forces that exist between molecules. They dictate several bulk properties, such as melting points, boiling points, and solubilities (miscibilities) of substances. Molar mass, molecular shape, and polarity affect the strength of different intermolecular forces, which influence the magnitude of physical properties across a family of molecules.
Temporary attractive forces like dispersion are present in all molecules, whether they are polar or nonpolar. They...
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Inhalational Anesthetics: Overview01:20

Inhalational Anesthetics: Overview

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Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
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Updated: Mar 7, 2026

Design and Use of a Full Flow Sampling System FFS for the Quantification of Methane Emissions
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Design and Use of a Full Flow Sampling System FFS for the Quantification of Methane Emissions

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Limited options for low-global-warming-potential refrigerants.

Mark O McLinden1, J Steven Brown2, Riccardo Brignoli3

  • 1Applied Chemicals and Materials Division, National Institute of Standards and Technology, 325 Broadway, Mailstop 647, Boulder, Colorado 80305, USA.

Nature Communications
|February 18, 2017
PubMed
Summary

New refrigerants are needed as hydrofluorocarbons face phase-down. Researchers found that ideal replacement fluids for air conditioning are slightly flammable, impacting system efficiency and capacity.

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Area of Science:

  • Environmental Science
  • Chemical Engineering
  • Thermodynamics

Background:

  • Hydrofluorocarbons (HFCs) are potent greenhouse gases used as refrigerants.
  • HFCs contribute significantly to climate change and are being phased down globally.
  • Development of environmentally benign and efficient refrigerant alternatives is crucial for air-conditioning systems.

Purpose of the Study:

  • To identify suitable replacement fluids for hydrofluorocarbons in air-conditioning systems.
  • To evaluate the chemical, environmental, thermodynamic, and safety properties of potential refrigerant candidates.
  • To assess the performance of promising fluids in small-scale air-conditioning systems.

Main Methods:

  • Screening a comprehensive chemical database using criteria for critical temperature and global warming potential.
  • Simulating refrigerant performance in optimized small air-conditioning systems.
  • Analyzing the trade-off between efficiency and capacity in realistic system conditions.

Main Results:

  • Only a limited number of pure fluids met the essential screening criteria for refrigerant replacement.
  • All identified potential replacement fluids exhibit at least slight flammability.
  • The efficiency-versus-capacity trade-off observed in ideal analyses was not present in realistic system simulations.
  • Maximum system efficiency was achieved at high volumetric refrigeration capacity, a range with few suitable fluid candidates.

Conclusions:

  • The search for ideal hydrofluorocarbon replacements reveals a scarcity of non-flammable options.
  • Slight flammability is an unavoidable characteristic of the most promising alternative refrigerants.
  • Realistic system modeling is essential for accurately predicting refrigerant performance and optimizing air-conditioning efficiency.