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Association between ABO Blood Group and Risk of Congenital Heart Disease: A 6-year large cohort study

Bailing Zu1, Guoling You2, Qihua Fu2

  • 1Department of Laboratory Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Scientific Reports
|February 18, 2017
PubMed

Insights

Individuals with blood group A have a reduced risk of developing isolated congenital heart disease (CHD). This finding suggests ABO blood group may serve as a potential marker for CHD risk assessment.

Area of Science:

  • Cardiovascular Research
  • Genetics and Genomics
  • Public Health

Background:

  • The ABO blood group is linked to coronary heart disease, but its association with congenital heart disease (CHD) remains unclear.
  • Previous studies on ABO blood group and CHD risk have yielded inconsistent results.
  • Understanding these associations can aid in identifying individuals at higher risk for CHD.

Purpose of the Study:

  • To investigate the potential relationship between ABO blood group and the risk of congenital heart disease (CHD).
  • To evaluate ABO blood group as a potential predictive marker for CHD.
  • To analyze the association of ABO blood group with specific CHD subgroups.

Main Methods:

  • A large cohort study involving 39,042 consecutive inpatients (19,795 with CHD and 19,247 controls).
  • Multivariable logistic regression analysis was employed to assess the roles of ABO blood group, gender, and Rh factor in CHD risk.
  • Stratification analysis, adjusted for gender, was used to examine associations between ABO blood group and CHD subgroups.

Main Results:

  • Individuals with blood group A showed a decreased risk for isolated CHD (OR 0.82; 95% CI, 0.78-0.87) in the overall cohort analysis.
  • This finding was consistently replicated in independent subgroup analyses.
  • No significant associations were found for other blood groups or non-isolated CHD.

Conclusions:

  • ABO blood group, specifically blood group A, may play a role in the risk of developing isolated congenital heart disease.
  • The ABO blood group could potentially serve as a novel, non-invasive marker for CHD risk stratification.
  • Further research is warranted to confirm these findings and elucidate the underlying mechanisms.

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