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Related Concept Videos

Postsynaptic Potential (PSP)01:32

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Related Experiment Video

Updated: Mar 7, 2026

Preparation of Synaptoneurosomes from Mouse Cortex using a Discontinuous Percoll-Sucrose Density Gradient
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Proteomic Analysis of Postsynaptic Protein Complexes Underlying Neuronal Plasticity.

Anthony J Baucum1

  • 1Department of Biology, Stark Neurosciences Research Institute, Indiana University-Purdue University Indianapolis , 723 W. Michigan St., Indianapolis, Indiana 46202, United States.

ACS Chemical Neuroscience
|February 18, 2017
PubMed
Summary

Proteomics studies reveal key postsynaptic protein complexes essential for neuronal communication and synaptic plasticity. Understanding these complexes aids in diagnosing and treating neurological disorders.

Keywords:
Mass spectrometryN-methyl-d-aspartate receptorcalcium/calmodulin-dependent protein kinase IIpostsynaptic densitypostsynaptic density protein 95signalingα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Biochemistry

Background:

  • Neuronal communication relies on dynamic regulation of postsynaptic molecules.
  • Protein expression and post-translational modifications are crucial for synaptic organization.
  • Understanding these processes is vital for synaptic plasticity and function.

Purpose of the Study:

  • To review proteomics-based approaches for identifying postsynaptic protein complexes.
  • To highlight the role of these complexes in synaptic physiology and pathology.
  • To discuss emerging technologies for analyzing these protein interactions.

Main Methods:

  • Qualitative and quantitative proteomics techniques over the past 20 years.
  • Focus on protein complexes associated with key synaptic proteins.
  • Analysis of data from various proteomics studies.

Main Results:

  • Identification of numerous postsynaptic protein complexes.
  • Established the foundation for understanding synaptic physiology.
  • Provided insights into synaptic signaling perturbations in pathologies.

Conclusions:

  • Proteomics has been instrumental in mapping postsynaptic protein complexes.
  • This knowledge is critical for understanding normal brain function.
  • Further research using emerging technologies will advance synaptic biology and disease understanding.